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Regulatory press release

BrainCool receives supplementary EU grant of approximately SEK 6 million for the COTTIS 2 study and strengthens its clinical team

BrainCool
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BrainCool AB (publ) today announces that the company has been awarded a grant of approximately SEK 6 million from the EU to support the ongoing clinical study COTTIS 2, which aims to generate efficacy and safety data for RhinoChill® – the next-generation system for medical precision cooling. At the same time, BrainCool is strengthening its clinical organization by appointing a project manager to support and accelerate study-related work.

Funding for COTTIS 2 has been secured through grants within the framework of an EU project and through direct financing by BrainCool. The deadline for the EU project expired at the end of May 2025. Upon the project’s conclusion, a final reconciliation of actual study expenses was carried out, resulting in BrainCool being awarded an additional approximately SEK 6 million in EU grants. This disbursement constitutes a non-budgeted capital contribution for the company.

At the same time, BrainCool is strengthening its clinical organization with a specialized project manager who has extensive experience managing clinical trials across the medical device and pharmaceutical sectors. The project manager will be contracted as a part-time consultant to focus exclusively on the COTTIS 2 study, in collaboration with the external CRO. In addition to her extensive experience in clinical studies, she has worked at a pharmaceutical company in Germany and has solid experience collaborating with local investigators and hospitals.

“The COTTIS 2 study is one of our most important projects. The results from the pilot study COTTIS 1 were very encouraging, and provided a positive outcome in COTTIS 2, RhinoChill would have the potential to transform stroke treatment globally. The additional capital contribution to BrainCool from the EU enables us to strengthen our clinical team and intensify our collaboration with the principal investigator, Professor Jürgen Bardutzky, and other involved stakeholders in order to accelerate the execution of the study,” comments Jon Berg, CEO of BrainCool.

For more information:
Jon Berg - CEO
+46 722 50 91 19
E-mail: jon.berg@braincool.se

About BrainCool
BrainCool AB (publ) is one of the world's leading companies in rapid precision cooling of patients to save lives and reduce secondary injuries in sudden cardiac arrest and stroke, as well as to counteract chemotherapy-related side effects. After successfully developing its first cooling system, the BrainCool™ System, and signing a distribution agreement with the global medtech company ZOLL®, the company is now focusing on bringing another innovative product, the RhinoChill® System, to the market. The RhinoChill® System has unique properties that make it possible to cool patients who have suffered cardiac arrest even before they reach the hospital and at the same time opens opportunities to significantly improve treatment outcomes in surgical removal of blood clots (thrombectomy) in connection with stroke. The global market for medical cooling is already estimated to be between SEK 8 and 12 billion.
 
The share is listed on Nasdaq First North Growth Market in Stockholm.

BrainCool's Certified Adviser is Eminova Fondkommission AB, +46 (0)8 - 684 211 00, adviser@eminova.se, www.eminova.se

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BrainCool receives supplementary EU grant of approximately SEK 6 million for the COTTIS 2 study and strengthens its clinical team

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