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Analyst Comment

ExpreS2ion: Update on progress in Oxford-led malaria vaccine programs

By Michael FriisHead of Equities
ExpreS2ion Biotech Holding

Today, ExpreS2ion provided an update on the progress made during the third quarter across its malaria vaccine programs led by the University of Oxford.

Two ongoing studies have now reached full recruitment status and are moving toward data analysis, while two new studies have begun recruitment, with completion targeted for late 2026 and mid-2027, respectively.

In total, ten Oxford-led malaria vaccine studies using ExpreS2ion’s ExpreS2 platform remain active. Six of these are Phase I trials focused on assessing safety, tolerability, and early immune responses, while four are Phase II trials evaluating the strength and durability of immune responses as well as early efficacy signals.

Further data readouts are expected from late 2025 and into 2026/27.

The company reiterated the potential shareholder value embedded in these malaria projects but also noted that publicly funded studies typically carry lower direct revenue potential. The key value for shareholders remain:

  • Licensing opportunities, such as the ongoing term-sheet discussions with Serum Institute of India Pvt. Ltd. (SIIPL), which include malaria candidates.
  • Validation of the ExpreS2 platform in human clinical settings.
  • Increased visibility of ExpreS2ion’s technology across global health programs.

Disclaimer: HC Andersen Capital receives payment from ExpreS2ion Biotechnologies for a Digital IR agreement. Michael Friis, 12.35, 10/11-2025 

ExpreS2ion is a Danish-based biotech company listed in Sweden. The company develops a portfolio of vaccines for diseases such as COVID-19, influenza, and breast cancer through the use of its non-viral cell-based expression system, ExpreS2, which is recognized for handling protein challenges. ExpreS2ion has developed Expres2, which is a technology platform for efficient and fast non-clinical development and production of complex proteins for new vaccines and diagnostics. The company’s current primary product is the corona vaccine candidate, ABNCoV2 in phase 2, co-developed with its partner, AdaptVac of which ExpreS2ion owns 34%. The vaccine candidate has been licensed to Bavarian Nordic has global commercialization rights and responsibility for further clinical development of the vaccine and is expected to initiate phase 3 testing for the product candidate in the first half of 2022.

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