ExpreS2ion Biotechnologies: First Immunogenicity Confirmation from Breast Cancer Study
ExpreS2ion today announced the first immunogenicity results from one patient after six weeks of treatment. The data indicate that the vaccine is triggering a significant immune response.
Read the full announcement here: https://www.inderes.dk/releases/expres2ion-biotechnologies-expres2ion-reports-first-immunogenicity-data-from-her2-breast-cancer-vaccine-es2b-c001-phase-i-trial
Blood samples taken before dosing (baseline) and after the second dose at three weeks showed a significant increase in HER2-specific antibodies compared to pre-dose levels. This confirms that the vaccine can activate the human immune system through its intended mechanism of action.
The initial findings support further evaluation of ES2B-C001 as a novel immunotherapeutic strategy for HER2-expressing breast cancer. More data is expected to be published on an ongoing basis. In connection with the Q2 2025 report, the company confirmed that interim primary endpoint data on safety and tolerability are still expected in mid-2026.
That said, this remains very early-stage data. Given the limited dataset, it may still be too early for the market to assign an increased probability-adjusted value in financial models.
You can read more about the priced-in probability in our one-pager here: https://www.inderes.dk/files/f55bb2e1-9b15-4a8b-a8b5-4a60a35c9bfe
ExpreS2ion Biotechnologies is a Danish pharmaceutical company focused on the development of vaccines through its ExpreS2 production platform in combination with AdaptVac's VLP technology.
Disclaimer: HC Andersen Capital receives payment from ExpreS2ion Biotechnologies for a Digital IR agreement. Michael Friis, 12:08, 04-09-2025
