contentSlug

type

ContentSlug_ContentQuery

slug

ContentPageContentQuery

content

trendingContent

query ContentSlug_ContentQuery(
  $contentSlug: String!
  $type: [ContentType!]
) {
  ...ContentPageContentQuery_13QmVO
}

fragment CompanyDetails_Content on Content {
  __isContent: __typename
  companies {
    name
    description
    pageUrl
    id
  }
}

fragment ContentBasicInfo on Content {
  __isContent: __typename
  id
  type
  title
  lang
  companies {
    viewerIsFollowing
    id
    name
    pageUrl
  }
  tags {
    viewerIsFollowing
    id
    name
    pageUrl
  }
  ...PublishingDetails
  ...Reactions
}

fragment ContentMetadata on Content {
  __isContent: __typename
  type
  title
  lang
  pageUrl
  alternatePageUrls: translations {
    __typename
    pageUrl
    lang
  }
  imgUrl
  description
  ... on Video {
    liveTime
    videoUrl
  }
  ... on Webcast {
    liveTime
    videoUrl
  }
}

fragment ContentPageContentQuery_13QmVO on Query {
  content(slug: $contentSlug, type: $type) {
    __typename
    id
    type
    title
    isPremium
    lang
    htmlBody
    summary
    companies {
      forum {
        latestPosts {
          ...ForumPosts
        }
      }
      name
      id
      viewerIsFollowing
      pageUrl
      defaultInstrument {
        isin
        id
        marketOpen
        marketClose
        marketplace {
          region
        }
        returns {
          total
        }
      }
    }
    tags {
      viewerIsFollowing
      id
      name
      pageUrl
    }
    createdAt
    ... on Video {
      liveTime
    }
    ... on Webcast {
      liveTime
    }
    slug
    ... on CompanyReport {
      reportUrl
    }
    ... on ThirdPartyCompanyReport {
      reportUrl
    }
    ... on StockExchangeRelease {
      reportUrl
    }
    ...ContentBasicInfo
    ...ContentMetadata
    ...PriceAndRecommendation_Content
    ...CompanyDetails_Content
    ...ReportLink_Content
    ...KeyFigures_Content
  }
  ...TrendingContent_1jQ2Cn
}

fragment ForumPosts on ForumPost {
  text
  likesCount
  url
  author
  postedAt
  authorImgUrl
}

fragment KeyFigures_Content on Content {
  __isContent: __typename
  companies {
    defaultInstrument {
      estimateData {
        modelType
        reportingCurrency
      }
      snapshot {
        transaction {
          date
          actualized {
            year
            quarter
            revenue
            revenueGrowth
            ebitAdjusted
            ebitReported
            ebitda
            enterpriseValue
            epsAdjusted
            dividend
            dividendYield
            sharePrice
          }
          estimates {
            year
            quarter
            revenue
            revenueGrowth
            ebitAdjusted
            ebitReported
            ebitda
            enterpriseValue
            epsAdjusted
            dividend
            dividendYield
            sharePrice
          }
        }
      }
      id
    }
    id
  }
}

fragment PriceAndRecommendation_Content on Content {
  __isContent: __typename
  createdAt
  companies {
    name
    pageUrl
    defaultInstrument {
      priceData {
        tradeCurrency
      }
      snapshot {
        priceData {
          date
          lastPrice
          tradeCurrency
        }
        transaction {
          date
          recommendation
          targetPrice
        }
        prevTransaction {
          recommendation
        }
      }
      id
    }
    id
  }
}

fragment PublishingDetails on Content {
  __isContent: __typename
  createdAt
  publishers {
    name
    imgUrl
  }
  authors {
    __typename
    id
    name
    slug
    imgUrl
    jobTitle
  }
  ... on Video {
    liveTime
  }
  ... on Webcast {
    liveTime
  }
}

fragment Reactions on Content {
  __isContent: __typename
  id
  reactionGroups {
    reactionType
    reactionsCount
    viewerReacted
  }
}

fragment ReportLink_Content on Content {
  __isContent: __typename
  type
  isPremium
  ... on CompanyReport {
    reportUrl
  }
  ... on ThirdPartyCompanyReport {
    reportUrl
  }
  ... on StockExchangeRelease {
    reportUrl
  }
}

fragment TrendingContent_1jQ2Cn on Query {
  trendingContent(type: ARTICLE) {
    __typename
    id
    title
    lang
    pageUrl
    createdAt
    type
    imgUrl
    companies {
      squareLogoUrl
      name
      id
    }
    authors {
      __typename
      imgUrl
      id
    }
    publishers {
      imgUrl
    }
  }
}


promising-results-farons-bexmab-blood-cancer-study

__typename

title

isPremium

lang

htmlBody

summary

companies

createdAt

publishers

authors

reactionGroups

pageUrl

translations

imgUrl

description

Analytiker

Atte Riikola

Faron is a global, clinical-stage biopharmaceutical company, focused on tackling cancers via novel immunotherapies. Its mission is to bring the promise of immunotherapy to a broader population by uncovering novel ways to control and harness the power of the immune system. The Company's lead asset is bexmarilimab, a novel anti-Clever-1 humanized antibody, with the potential to remove immunosuppression of cancers through reprogramming myeloid cell function. Bexmarilimab is being investigated in Phase I/II clinical trials as a potential therapy for patients with hematological cancers in combination with other standard treatments.

Jeg spurgte, fordi jeg overvejede, om forskningsmetoden overhovedet er relevant information for en investor. Tilsyneladende ikke? Jeg finder flere kilder, ifølge hvilke TP53m-allelstatus ikke kan opnås pålideligt med VAF-metoden, men at NGS er nødvendigt. “… cases with seemingly monoallelic TP53^MT likely contain cryptic clones with biallelic TP53 inactivation, but their detection is not possible using traditional sequencing methods. Even after estimating the clonality of del17p or uniparental disomy (UPD), such TP53 configuration analysis is hampered by essential flaws such as the inability to: i) detect and quantify the biallelic fraction in cases with smaller variant allelic frequency (VAF) or ii) prove the presence of subclonal mosaicisms with two different TP53 mutant clones using traditional bulk DNA sequencing methods.”                   PubMed Central (PMC)              Novel Scheme for Defining the Clinical Implications of TP53 Mutations in...    TP53 mutations (TP53MT) occur in diverse genomic configurations. Particularly, biallelic inactivation is associated with poor overall survival in cancer. Lesions affecting only one allele might not be directly leukemogenic, questioning the presence...

Jeg ved det ikke. Man kan undersøge det, hvis man er interesseret. Men molekylærgenetik skal selvfølgelig afklares før behandling og MRD-situationen efter behandling, så de kan ikke opnås med samme analyse…

Hvad siger din ekspertise; kan mono/bialleliteten af TP53-mutationen bestemmes uden NGS?

Clark Kent, kan du vurdere denne bexmarilimab-udvikling ud fra den synsvinkel, hvor meget data konkurrerende aktører ville få til deres eget udviklingsarbejde, hvis al offentliggjort data var virkelig detaljeret, næsten perfekt? Jeg tænker selv på dette ud fra en anden uddannelsesmæssig baggrund. Generelt er der ingen grund til at offentliggøre for detaljeret information om et produkt under udvikling, før det er kommet på markedet. Baseret på synlige resultater (f.eks. dæksammenligning) er produktet simpelthen bedre, og dermed går handlen. Og de detaljer (om blandingen osv.) offentliggøres ikke.

Netop, NGS er meget mere præcis end traditionel flowcytometri. Fortalte Faron, hvilken der blev brugt - selvfølgelig ikke. Jeg prøvede lidt, men de MRD-data, der blev vist på et enkelt slide, er som sådan uforlignelige og fuldstændig ubrugelige. Nå, det blev heller ikke nævnt i pressemeddelelsen.

ascopost.com              Amer Zeidan, MBBS, on TP53-Mutated Higher-Risk MDS: Bexmarilimab Plus...

Faron Pharmaceuticals

On Wednesday, Faron Pharmaceuticals published new positive results from the BEXMAB study to examine the efficacy of the company's precision immunotherapy treatment (bexmarilimab) for a number of malignant haematological tumors, or blood cancers. 

Translation: Original comment published in Finnish on 7/19/2023 at 6:40 am. On Wednesday, Faron Pharmaceuticals <a href="https://www.inderes.se/releases/faron-pharmaceuticals-oy-bexmab-study-update-4">published</a> new positive results from the BEXMAB study to examine the efficacy of the company's precision immunotherapy treatment (bexmarilimab) for a number of malignant haematological tumors, or blood cancers. Faron also stated that they plan to file the first Biologics License Application (BLA) to FDA in H1’25. According to the company, the data received so far in the study supports moving to clinical Phase II. This move is already included in our modeling as a very likely scenario in our estimates. So there is no need for major estimate changes, but we will review our assumptions in connection with our Q2 pre-comment. Our latest update on Faron is available <a href="https://www.inderes.se/research/faron-pharmaceuticals-bexmab-studys-good-momentum-supports-valuation">here.</a>

	2022	23e	24e
Omsætning	0,0	0,0	0,0
vækst-%
EBIT (adj.)	-27,4	-15,8	-3,1
EBIT-% (adj.)	-685.650,0 %	-394.522,5 %	-76.864,0 %
EPS (adj.)	-0,48	-0,25	-0,05
Udbytte	0,00	0,00	0,00
Udbytte %
P/E (adj.)	neg.	neg.	neg.
EV/EBITDA	neg.	neg.	neg.

Promising results from Faron's BEXMAB blood cancer study

Key Estimate Figures17.04.2023

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