ExpreS2ion Biotechnologies: First Patient Dosed in Phase 1 Clinical Trial of ES2B-C001
ExpreS2ion today announced that the first patient has been dosed with ES2B-C001, and the treatment was well tolerated. This successful dosing marks the transition of the trial from the enrollment phase to the treatment phase. The primary endpoint of the study is to evaluate safety, tolerability, and the maximum tolerated dose. The secondary endpoints include assessing the immunological response and signs of clinical efficacy, such as tumor size reduction.
In today’s announcement, the company also confirmed the timeline (Q3 2025) for a potential response to the amendment. This amendment is intended to support patient enrollment further by enabling the evaluation of the breast cancer vaccine candidate, ES2B-C001, in combination with antibody-drug conjugates (ADCs) and expanding the number of study sites.
At the Q1 2025 results presentation, the CEO stated that the company is still on track to potentially receive preliminary outcomes before the end of this year, with further results expected in 2026. With an anticipated 40-48 weeks to interim data, this timeline remains feasible.
Read the full announcement here:
https://www.inderes.dk/releases/expres2ion-biotechnologies-expres2ion-announces-dosing-of-first-patient-in-phase-i-clinical-trial-of-es2b-c001-its-novel-therapeutic-breast-cancer-immunotherapy
Disclaimer: HC Andersen Capital receives payment from ExpreS2ion Biotechnologies for a Digital IR/Corporate Visibility subscription agreement. Michael Friis, 15:30, 23-06-2025
ExpreS2ion er en biotekvirksomhed med base i Danmark, men børsnoteret i Sverige. Virksomheden udvikler en portefølje af vacciner mod sygdomme som COVID-19, influenza og brystkræft gennem brugen af dets cellebaserede ekspressionssystem, ExpreS2, som er anerkendt for at håndtere protein udfordringer. ExpreS2ion har udviklet Expres2, som er en teknologiplatform til effektiv og hurtig ikke-klinisk udvikling og produktion af komplekse proteiner til nye vacciner og diagnostik. På nuværende tidspunkt er selskabets primære produkt corona-vaccinekandidaten, ABNCoV2 som er i fase 2, udviklet sammen med sin partner, AdaptVac, hvoraf ExpreS2ion ejer 34%. Vaccinekandidatens licensret tilhører Bavarian Nordic som har globale kommercialiseringsrettigheder og ansvar for yderligere klinisk udvikling af vaccinen.
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