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Analytikerkommentar

ExpreS2ion Biotechnologies: First Immunogenicity Confirmation from Breast Cancer Study

Af Michael FriisHead of Equities
ExpreS2ion Biotech Holding

ExpreS2ion today announced the first immunogenicity results from one patient after six weeks of treatment. The data indicate that the vaccine is triggering a significant immune response.

Read the full announcement here: https://www.inderes.dk/releases/expres2ion-biotechnologies-expres2ion-reports-first-immunogenicity-data-from-her2-breast-cancer-vaccine-es2b-c001-phase-i-trial

Blood samples taken before dosing (baseline) and after the second dose at three weeks showed a significant increase in HER2-specific antibodies compared to pre-dose levels. This confirms that the vaccine can activate the human immune system through its intended mechanism of action.

The initial findings support further evaluation of ES2B-C001 as a novel immunotherapeutic strategy for HER2-expressing breast cancer. More data is expected to be published on an ongoing basis. In connection with the Q2 2025 report, the company confirmed that interim primary endpoint data on safety and tolerability are still expected in mid-2026.

That said, this remains very early-stage data. Given the limited dataset, it may still be too early for the market to assign an increased probability-adjusted value in financial models.

You can read more about the priced-in probability in our one-pager here: https://www.inderes.dk/files/f55bb2e1-9b15-4a8b-a8b5-4a60a35c9bfe

ExpreS2ion Biotechnologies is a Danish pharmaceutical company focused on the development of vaccines through its ExpreS2 production platform in combination with AdaptVac's VLP technology.

Disclaimer: HC Andersen Capital receives payment from ExpreS2ion Biotechnologies for a Digital IR agreement. Michael Friis, 12:08, 04-09-2025 

ExpreS2ion er en biotekvirksomhed med base i Danmark, men børsnoteret i Sverige. Virksomheden udvikler en portefølje af vacciner mod sygdomme som COVID-19, influenza og brystkræft gennem brugen af dets cellebaserede ekspressionssystem, ExpreS2, som er anerkendt for at håndtere protein udfordringer. ExpreS2ion har udviklet Expres2, som er en teknologiplatform til effektiv og hurtig ikke-klinisk udvikling og produktion af komplekse proteiner til nye vacciner og diagnostik. På nuværende tidspunkt er selskabets primære produkt corona-vaccinekandidaten, ABNCoV2 som er i fase 2, udviklet sammen med sin partner, AdaptVac, hvoraf ExpreS2ion ejer 34%. Vaccinekandidatens licensret tilhører Bavarian Nordic som har globale kommercialiseringsrettigheder og ansvar for yderligere klinisk udvikling af vaccinen.

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