contentSlug

type

ContentSlug_ContentQuery

slug

ContentPageContentQuery

content

trendingContent

query ContentSlug_ContentQuery(
  $contentSlug: String!
  $type: [ContentType!]
) {
  ...ContentPageContentQuery_13QmVO
}

fragment CompanyDetails_Content on Content {
  __isContent: __typename
  companies {
    name
    description
    pageUrl
    id
  }
}

fragment ContentBasicInfo on Content {
  __isContent: __typename
  id
  type
  title
  lang
  companies {
    viewerIsFollowing
    id
    name
    pageUrl
  }
  tags {
    viewerIsFollowing
    id
    name
    pageUrl
  }
  ...PublishingDetails
  ...Reactions
}

fragment ContentMetadata on Content {
  __isContent: __typename
  type
  title
  lang
  pageUrl
  alternatePageUrls: translations {
    __typename
    pageUrl
    lang
  }
  imgUrl
  description
  ... on Video {
    liveTime
    videoUrl
  }
  ... on Webcast {
    liveTime
    videoUrl
  }
}

fragment ContentPageContentQuery_13QmVO on Query {
  content(slug: $contentSlug, type: $type) {
    __typename
    id
    type
    title
    isPremium
    lang
    htmlBody
    summary
    companies {
      forum {
        latestPosts {
          ...ForumPosts
        }
      }
      name
      id
      viewerIsFollowing
      pageUrl
      defaultInstrument {
        isin
        id
        marketOpen
        marketClose
        marketplace {
          region
        }
        returns {
          total
        }
      }
    }
    tags {
      viewerIsFollowing
      id
      name
      pageUrl
    }
    createdAt
    ... on Video {
      liveTime
    }
    ... on Webcast {
      liveTime
    }
    slug
    ... on CompanyReport {
      reportUrl
    }
    ... on ThirdPartyCompanyReport {
      reportUrl
    }
    ... on StockExchangeRelease {
      reportUrl
    }
    ...ContentBasicInfo
    ...ContentMetadata
    ...PriceAndRecommendation_Content
    ...CompanyDetails_Content
    ...ReportLink_Content
    ...KeyFigures_Content
  }
  ...TrendingContent_1jQ2Cn
}

fragment ForumPosts on ForumPost {
  text
  likesCount
  url
  author
  postedAt
  authorImgUrl
}

fragment KeyFigures_Content on Content {
  __isContent: __typename
  companies {
    defaultInstrument {
      estimateData {
        modelType
        reportingCurrency
      }
      snapshot {
        transaction {
          date
          actualized {
            year
            quarter
            revenue
            revenueGrowth
            ebitAdjusted
            ebitReported
            ebitda
            enterpriseValue
            epsAdjusted
            dividend
            dividendYield
            sharePrice
          }
          estimates {
            year
            quarter
            revenue
            revenueGrowth
            ebitAdjusted
            ebitReported
            ebitda
            enterpriseValue
            epsAdjusted
            dividend
            dividendYield
            sharePrice
          }
        }
      }
      id
    }
    id
  }
}

fragment PriceAndRecommendation_Content on Content {
  __isContent: __typename
  createdAt
  companies {
    name
    pageUrl
    defaultInstrument {
      priceData {
        tradeCurrency
      }
      snapshot {
        priceData {
          date
          lastPrice
          tradeCurrency
        }
        transaction {
          date
          recommendation
          targetPrice
        }
        prevTransaction {
          recommendation
        }
      }
      id
    }
    id
  }
}

fragment PublishingDetails on Content {
  __isContent: __typename
  createdAt
  publishers {
    name
    imgUrl
  }
  authors {
    __typename
    id
    name
    slug
    imgUrl
    jobTitle
  }
  ... on Video {
    liveTime
  }
  ... on Webcast {
    liveTime
  }
}

fragment Reactions on Content {
  __isContent: __typename
  id
  reactionGroups {
    reactionType
    reactionsCount
    viewerReacted
  }
}

fragment ReportLink_Content on Content {
  __isContent: __typename
  type
  isPremium
  ... on CompanyReport {
    reportUrl
  }
  ... on ThirdPartyCompanyReport {
    reportUrl
  }
  ... on StockExchangeRelease {
    reportUrl
  }
}

fragment TrendingContent_1jQ2Cn on Query {
  trendingContent(type: ARTICLE) {
    __typename
    id
    title
    lang
    pageUrl
    createdAt
    type
    imgUrl
    companies {
      squareLogoUrl
      name
      id
    }
    authors {
      __typename
      imgUrl
      id
    }
    publishers {
      imgUrl
    }
  }
}


a-publication-in-nature-reviews-urology-summarizes-the-scientific-basis-for-selectimmunes-drug-development-strategy

__typename

title

isPremium

lang

htmlBody

summary

companies

createdAt

publishers

authors

reactionGroups

pageUrl

translations

imgUrl

description

Innovative solutions are needed for the treatment of bacterial infections and a range of antibacterial molecules have been explored as alternatives to traditional antibiotics. A different approach...

Innovative solutions are needed for the treatment of bacterial infections and a range of antibacterial molecules have been explored as alternatives to traditional antibiotics. A different approach is to explore the immune response for new ways of making the antibacterial defence more efficient. The immune system has a dual role as protector and cause of disease and new therapies aim to increase the protective effect while inhibiting excessive innate immune responses that cause symptoms and tissue pathology during infection.The concept of innate immunomodulation therapy has been developed successfully in urinary tract infections based on detailed studies of innate immune activation and disease pathogenesis. Effective, disease-specific, immuno-modulatory strategies have been successfully implemented in experimental models. Inhibiting interferon regulatory factor 7, using small interfering RNA is protective in a murine acute pyelonephritis model. In acute cystitis, targeting overactive immune effector molecules such as IL- 1β, MMP-7 and the pain-sensing receptor NK1R are successful in vivo.The IL-1 receptor antagonist (IL-1RA, anakinra) is now being developed for patients with severe bladder pain syndrome and studies in patients withrecurrent acute cystitis are ongoing. Off label treatment reduced bladder pain, increased the quality of life and allowed responding patients to return to a more normal lifestyle. At the molecular level, treatment inhibited destructive neuro-inflammation, and pain sensing was lowered.The review summarizes the molecular basis of the excessive innate immune responses that cause symptoms and pathology during urinary tract infections. The review also describes successful examples of innate immunomodulation therapy, making it a realistic option for treating these conditions."We are proud to be invited by Nature Reviews Urology to summarize this topic. The Nature Reviews are highly prestigious, with a broad readership," says Ines Ambite, research scientist at Lund University and R&amp;D coordinator, SelectImmune Pharma."The potential of immunotherapy is considerable and there is a great need for alternatives to conventional antibacterial therapy," says Catharina Svanborg, Professor and Founder of SelectImmune Pharma

A publication in Nature Reviews Urology summarizes the scientific basis for SelectImmune's drug development strategy.